2nd International Pulmonary Hypertension / Heart Failure Symposium

Focus on Structural Heart Disease, Right Ventricular Dysfunction and Stem Cell Therapy

March 26 – 27, 2022 (1.5 day meeting)
Berlin, Germany

Hosted by The European Pediatric Pulmonary Vascular Disease Network
Venue: GLS Campus Berlin, Kastanienallee 82

Conference Chairs and Scientific Organizers:
Georg Hansmann and Martin Köstenberger

Endorsed by:
Register now!

Welcome to Berlin!

We cordially invite you to participate in the 2nd international, interdisciplinary “Pulmonary Hypertension/ Heart Failure Symposium” with focus on structural heart disease, right ventricular dysfunction and stem cell therapy.

The science presented at this symposium is not pediatric-specific.

A strength of this meeting is its multidisciplinary nature – bringing together basic-translational scientists and clinicians (cardiologists, pulmonologists, neonatologists, cardiothoracic surgeons, intensivists). In six different sessions spread over 1.5 days, this meeting will update you on recent discoveries and innovations, and addresses several important paradigm shifts in the field of pulmonary hypertension and heart failure:

  • Pulmonary vascular disease (PVD) relates in large part to increased cell proliferation, metabolic dysfunction, resistance to apoptosis, and inflammation (rather than vasoconstriction) – „cancer hypothesis“.

  • Stem cells, progenitor and differentiated blood cells play important roles in development of PVD and pulmonary arterial hypertension (PAH). Several pre-clinical studies have been reported the efficacy of stem cell therapy for PVD and heart failure, and the first phase Ia/b and II studies are underway.

  • Performance of the right ventricle, and its interaction with the left ventricle, is the key determinant of prognosis in PAH. Thus, innovative, non-invasive imaging of the hypertensive RV-PA unit, and the search for direct RV treatment targets, are paramount.

  • A dedicated session on Structural Heart Disease will deal with Diagnostics and Therapeutic Interventions on the RV-PA Unit and Single Ventricles.

  • Clinical trials and new trial designs related to pulmonary hypertension, ARDS, HFpEF/CpcPH and structural heart disease will be highlighted throughout this meeting.

Histology of advanced PVD

Pulmonary vascular disease (PVD) is characterized by progressive obliteration of pulmonary arterioles leading to increased pulmonary vascular resistance (PVR), pulmonary arterial hypertension (PAH), right heart failure, and death in ≈25-60% of patients 5 years after diagnosis. The pathobiology of PAH is complex and multifactorial, and none of the current therapies has been shown to be universally effective or able to reverse advanced pulmonary vascular disease, characterized by plexiform vascular lesions (image).

08:00 – 12:30h  |  Saturday Morning Program

*confirmed speakers, chairs and panelists

  • 07:45 – 08:30h  |  Registration

  • 08:30 – 10:30h  |  Session #1

Topic: Angiogenesis and Vascular Remodeling

  • 8:30h: Welcome
  • 8:35h: Keynote lecture #1 (20min.+5min)
  • 9:00h: Invited Talk (15min+5min)
  • 9:20h: Invited Talk (15min+5min)
  • 9:40h: Invited Talk (15min+5min)
  • 10:00h: Oral Abstract (10min+5min)
  • 10:15h: Oral Abstract (10min+5min)
  • 10:30 – 11:00h  | Coffee Break

Industry Exhibition, Poster Set Up (#1-10)

  • 11:00 – 12:30h  |  Session #2

Topic: Stem Cell Therapy for PVD and Heart Failure

  • 11:00h: Keynote lecture #2 (20min.+5min) – Joe Wu*, Stanford
  • 11:30h: Invited Talk (15min+5min)
  • 11:50h: Invited Talk (15min+5min)
  • 12:10h: Invited Talk (15min+5min)

12:30 – 14:00h  |  Buffet Lunch

Industry Exhibition, Poster Session
(posters #1-10 start at 13:00h)

The 2nd international, interdisciplinary “Pulmonary Hypertension/ Heart Failure Symposium” will host an Industry Exhibition and 2 Poster Sessions on March 26 and 27, 2022 from 10.30-11.00h. Both the Industry Exhibition and then poster sessions will take place at the conference venue GLS Campus Berlin and provides an opportunity for companies to present their work in the areas of pulmonary hypertension related to symposiums conference topics to a wider community of researchers from academia and industry. The session aims to encourage interaction and networking among companies, researchers and the audience.

The posters will display throughout each conference day and provide a platform for continuous interaction between the presenters, attendees and invited faculty.

14:00 – 17:30h  |  Saturday Afternoon Program

*confirmed speakers, chairs and panelists

  • 14:00 – 15:30h  |  Session #3

Topic: Cardiovascular Metabolism and Inflammation

  • 14:00h: Invited Talk (15min+5min)
  • 14:20h: Invited Talk (15min+5min)
  • 14:40h: Invited Talk (15min+5min)
  • 15:00h: Oral Abstract (10min+5min)
  • 15:15h: Oral Abstract (10min+5min)
  • 15:30 – 16:00h  |  Coffee Break

Industry Exhibition

  • 16:00 – 17:30h |  Session #4

Topic: Clinical Trials and New Trial Designs: Pulmonary Hypertension, ARDS, HFpEF/CpcPH, Structural Heart Disease

  • 16:00h: Invited Talk (15min+5min)
  • 16:20h: Invited Talk (15min+5min) – Martin Wilkins*, London, UK (new phase 3 imatinib RCT)
  • 16:40h: Invited Talk (15min+5min)
  • 17:00h: Oral Abstract (10min+5min)
  • 17:15h: Oral Abstract (10min+5min) or panel discussion

17:30 – 19:00h
Wine & Appetizers

Industry Exhibition
18:45h: poster take down

09:00 – 13:00h  |  Sunday Morning Program

*confirmed speakers, chairs and panelists

  • 08:30 – 08:50h  |  Poster Set Up

Posters #11-20

  • 09:00 – 10:30h  |  Session #1

Topic: Diagnostics and Therapeutic Interventions on the RV-PA Unit and Single Ventricles

  • 9:00h: Keynote lecture #3 (20min.+5min)
  • 9:30h: Invited Talk (15min+5min) – Werner Budts*, Leuven
  • 9:50h: Invited Talk (15min+5min)
  • 10:10h: Invited Talk (15min+5min)
  • 10:30 – 11:30h  |  Coffee Break

Industry Exhibition, Poster Session (posters #11-20)

  • 11:30  – 13:00h |  Session #2

Topic: Modern Imaging of PVD and Cardiac Dysfunction

  • 11:30h: Invited Talk (15min+5min)
  • 11:50h: Invited Talk (15min+5min)
  • 12:10h: Invited Talk (15min+5min) – Dunbar Ivy*, Denver (advanced echocardiography in PAH)
  • 12:30h: Oral Abstract (10min+5min)
  • 12:45h: Oral Abstract (10min+5min)
  • 13:00h  | Sojourn

Georg Hansmann on behalf of the European Pediatric Pulmonary Vascular Disease Network

Right Heart Failure

Transthoracic echocardiography (parasternal short axis view) shows RV hypertrophy, severe RV dilation and systolic RV dysfunction.

„Advanced Therapies for Pediatric Pulmonary Hypertension and Heart Failure“

Workshop | Friday, March 25, 2022 (9:00-17:00h) | Charité and DHZB, Germany

Hosted by
The European Pediatric Pulmonary
Vascular Disease Network

Charité Camous Virchow-Klinikum and DHZB, Berlin, Germany

5-10 Course Instructors
Max. 40 Participants
Flat rate 50,- EUR (in addition to symposium fee)

To register for this workshop please contact: workshop@pvdnetwork.org

Don’t miss our PH/HF Workshop!

Pediatric PH is caused by multiple underlying conditions, with and without congenital heart disease. The current management of pediatric patients with PH incorporates several different diagnostic and therapeutic modalities, which are used in a variety of settings ranging from ambulatory to intensive care. The aim of this workshop is to provide a contemporary overview of current diagnostic strategies and treatment approaches used in different forms of pediatric PH by means of hands-on teaching and small-group discussions. During the morning sessions (09.00-13.00) we will cover the following topics:

  • Echocardiographic assessment of PH and right heart function

  • Invasive assessment of pediatric PH and vasoreactivity testing

  • Principles of intensive care in pediatric PH with and without CHD

  • Extracorporal circulatory support in PH and RV failure

In the afternoon (14.00-17-00) we will discuss typical and rather rare case scenarios in pediatric PH. Participants are encouraged to bring their own cases and discuss them with faculty and the other participants. The workshop is intended for all medical personnel taking care of pediatric PH patients, such as pediatric residents, fellows, early-career pediatric cardiologists, pulmonologists and neonatologists. It will take place at the Department of Pediatric Cardiology, Charité Berlin and the Department of Congenital Heart Disease, German Heart Center Berlin (DHZB), both located at Virchow Campus of Charité University Hospital. We are looking forward to welcoming you in the heart of Berlin!

Symposium Venue

The GLS Campus is located in the heart of Berlin’s Prenzlauer Berg district. Surrounded by well known cafes, bars and restaurants, our symposium venue offers a unique combination of urban lifestyle and scientific retreat. Public transport is in walking distance.

Hotel recommendations

There is a variety of hotels next to our symposium venue. We recommend one in particular: The famous „Oderberger Hotel“ is located in walking distance from our symposium venue. The hotel used to be an impressive public bath a century ago. Now it accommodates tourists on a 4 star level.

Thanks for the support!