2nd International Pulmonary Hypertension / Heart Failure Symposium

Focus on Structural Heart Disease, Right Ventricular Dysfunction and Stem Cell Therapy

NEW DATE:

June 11 – 12, 2022 (1.5 day meeting)
Berlin, Germany

Hosted by The European Pediatric Pulmonary Vascular Disease Network
Venue: GLS Campus Berlin, Kastanienallee 82

Conference Chairs and Scientific Organizers:
Georg Hansmann and Martin Köstenberger

Endorsed by:
Laden...
Register now!

Welcome to Berlin!

We cordially invite you to participate in the 2nd international, interdisciplinary “Pulmonary Hypertension/ Heart Failure Symposium” with focus on structural heart disease, right ventricular dysfunction and stem cell therapy.

The science presented at this symposium is not pediatric-specific.

A strength of this meeting is its multidisciplinary nature – bringing together basic-translational scientists and clinicians (cardiologists, pulmonologists, neonatologists, cardiothoracic surgeons, intensivists). In six different sessions spread over 1.5 days, this meeting will update you on recent discoveries and innovations, and addresses several important paradigm shifts in the field of pulmonary hypertension and heart failure:

  • Pulmonary vascular disease (PVD) relates in large part to increased cell proliferation, metabolic dysfunction, resistance to apoptosis, and inflammation (rather than vasoconstriction) – „cancer hypothesis“.

  • Stem cells, progenitor and differentiated blood cells play important roles in development of PVD and pulmonary arterial hypertension (PAH). Several pre-clinical studies have been reported the efficacy of stem cell therapy for PVD and heart failure, and the first phase Ia/b and II studies are underway.

  • Performance of the right ventricle, and its interaction with the left ventricle, is the key determinant of prognosis in PAH. Thus, innovative, non-invasive imaging of the hypertensive RV-PA unit, and the search for direct RV treatment targets, are paramount.

  • A dedicated session on Structural Heart Disease will deal with Diagnostics and Therapeutic Interventions on the RV-PA Unit and Single Ventricles.

  • Clinical trials and new trial designs related to pulmonary hypertension, ARDS, HFpEF/CpcPH and structural heart disease will be highlighted throughout this meeting.

Histology of advanced PVD

Pulmonary vascular disease (PVD) is characterized by progressive obliteration of pulmonary arterioles leading to increased pulmonary vascular resistance (PVR), pulmonary arterial hypertension (PAH), right heart failure, and death in ≈25-60% of patients 5 years after diagnosis. The pathobiology of PAH is complex and multifactorial, and none of the current therapies has been shown to be universally effective or able to reverse advanced pulmonary vascular disease, characterized by plexiform vascular lesions (image).

08:30 – 12:30h  |  Saturday, June 11, 2022 | Morning Program

*confirmed speakers, chairs and panelists

  • 07:45 – 08:30h  |  Registration

  • 08:30 – 10:15h  |  Session #1

Topic: Angiogenesis and Vascular Remodeling

Chairs/Panelists: George Caputa*, Håkan Wåhlander*

  • 8:30h Welcome – Georg Hansmann*
  • 8:40h: Invited Talk (15min+5min) – Petra Knaus*, Berlin. Endothelial homeostasis and TGFbeta superfamily receptors in PAH
  • 9:00h: Invited Talk (15min+5min) – Grazyna Kwapiszewska*, Graz. Cellular heterogeneity of the vessel wall in pulmonary hypertension
  • 9:20h: Invited Talk (15min+5min) – Bradley A. Maron*, Boston. Platelet-endothelial adhesion in the pulmonary circulation
  • 9:40h: Invited Talk (15min+5min) – Maximilian Ackermann, Mainz*. Pulmonary Vascular Disease due to severe COVID-19
  • 10:00h: Oral Abstract (10min+5min) – Taslim Al-Hilal, El Paso*. On-chip capturing and enumeration of CECs identify the prion-like protein Doppel as a novel therapeutic target for PAH

  • 10:15 – 10:45h  | Break & Industry Exhibition

Poster Set Up

  • 10:45 – 12:15h  |  Session #2

Topic: Modern Imaging of Pulmonary Vascular Disease and Cardiac Dysfunction

Chairs/Panelists: Martin Koestenberger*, Boris Schmitt*

  • 10:45h: Invited Talk (15min+5min) – Eva Rog-Zielinska*, Freiburg. Nanostructure of transverse tubules and mitochondria in functional and failing cardiomyocytes
  • 11:05h: Invited Talk (15min+5min) – Min-Chi Ku*, Berlin. CMR detects microvascular dysfunction in cardiac hypertrophy (cine ASL-CMR)
  • 11:25h: Invited Talk (15min+5min) – Eike Nagel*, Frankfurt. Validation of CMR against invasive hemodynamics in patients with HFpEF (DECIPHER-HFpEF-DZHK12)
  • 11:45h: Oral Abstract (10min+5min) – Karin Tran-Lundmark*, Lund. X-ray phase contrast imaging of pulmonary vascular disease
  • 12:00h: Oral Abstract (10min+5min) – Stine Andersen, Aarhus*. PA-banding models of RV failure

12:30 – 14:00h  |  Buffet Lunch & Industry Exhibition, Poster Session

Poster Session (posters start at 13:15h), Poster moderators: Karin Tran-Lundmark*, Stine Andersen*

The 2nd international, interdisciplinary “Pulmonary Hypertension/ Heart Failure Symposium” will host an Industry Exhibition and 2 Poster Sessions. Both the Industry Exhibition and then poster sessions will take place at the conference venue GLS Campus Berlin and provides an opportunity for companies to present their work in the areas of pulmonary hypertension related to symposiums conference topics to a wider community of researchers from academia and industry. The session aims to encourage interaction and networking among companies, researchers and the audience.

The posters will display throughout each conference day and provide a platform for continuous interaction between the presenters, attendees and invited faculty.

14:00 – 18:00h  |  Saturday, June 11, 2022 | Afternoon Program

*confirmed speakers, chairs and panelists

  • 14:00 – 15:30h  |  Session #3

Topic: Diagnostics and Therapeutic Interventions on the RV-PA Unit and Single Ventricles

Chairs/Panelists: Dmitry Bobylev*, Mi-Young Cho*, Georg Hansmann*, Christoph Knosalla*

  • 14:00h: Invited Talk (15min+5min) – Werner Budts*, Leuven. Early detection and management of RV dysfunction (structural interventions, pharmacotherapy)
  • 14:20h: Invited Talk (15min+5min) – Johannes Nordmeyer*, Berlin. Stenting the RV-PA unit and interventional creation of restrictive ASDs in pre- and postcapillary PH
  • 14:40h: Invited Talk (15min+5min) – Allison Cabalka*, Rochester. Reverse Potts shunt (surgical, interventional) or lung transplantation – choosing the right procedure for individual patients with severe PAH
  • 15:00h: Oral Abstract (10min+5min) – Franziska Diekmann*, Hannover. RV recovery and clinial outcome in children with severe PAH undergoing lung transplantation
  • 15:15h: Oral Abstract (10min+5min) – Martin Köstenberger*, Graz. ECHO reference values of the endsystolic RV/LV ratio and LV eccentricity index in healthy and pulmonary hypertensive children

  • 15:30 – 16:15h  | Break & Industry Exhibition

  • 16:00 – 17:30h |  Session #4

Topic: Clinical Trials and New Trial Designs: Pulmonary Hypertension, ARDS, HF/CpcPH, Structural Heart Disease

Chairs/Panelists: Babar Hasan*, Werner Budts*

  • 16:15h: Invited Talk (15min+0min) – Marion Delcroix*, Leuven. Novel clinical PAH trial designs
  • 16:30h: Invited Talk (15min+0min) – Martin Wilkins*, London. The new PAH Imatinib RCT
  • 16:45h: Invited Talk (15min+0min) – Sylvia Nikkho*, Berlin. PVRI’s Innovative Drug Development Initiative (IDDI) and specific challenges in pediatric PAH trials
  • 17:00h: Invited Talk (15min+0min) – Hosan Hasan*, Hannover. Validation of the EPPVDN Pediatric PH Risk Score by CMR and speckle tracking echocardiography
  • 17:15h: Panel discussion, led by Babar Hasan* (30min) – chairs, speakers, panelists + audience

18:00 – 19:00h
Get Together (Wine)

18:45h: poster take down
Poster boards: 150 cm x 120 cm, blue, two-sided. Posters = A0 landscape

09:00 – 13:00h  |  Sunday, June 12, 2022 | Morning Program

*confirmed speakers, chairs and panelists

  • 08:30 – 08:50h  |  Poster Set Up

  • 09:00 – 10:30h  |  Session #1

Topic: Stem Cell Therapy for Pulmonary Vascular Disease and Heart Failure

Chairs/Panelists: Stephen Y. Chan*, Vesna Todorović*, Sophie van Linthout*

  • 09:00h: Keynote lecture (20min.+10min) – Stella Kourembanas*, Boston. Stem cell extracellular vesicles: key signaling and therapeutic vectors for cardiopulmonary diseases
  • 09:30h: Invited Talk (15min+5min) – Mingxia Gu*, Cincinnati. Reconstructing organotypic vasculature from iPSCs to study cardiopulmonary diseases
  • 09:50h: Invited Talk (15min+5min) – Georg Hansmann, Hannover*. First-in-human umbilical cord mesenchymal stem cell-derived treatment of severe pulmonary arterial hypertension
  • 10:10h: Invited Talk (15min+5min) – Norbert Hübner*, Berlin. The human heart at single cell resolution.

  • 10:30 – 11:30h  |  Break & Industry Exhibition, Poster Session

Poster Session, Poster Moderators: Michael Bader*, Babar Hasan*

  • 11:30  – 13:00h |  Session #2

Topic: Cardiovascular Metabolism and Inflammation

Chairs/Panelists: Bradley A. Maron*, Christoph Schmitt*

  • 11:30h: Invited Talk (15min+5min) – Stephen Y. Chan*, Pittsburgh. Intersections of RNA pathobiology with pulmonary vascular disease and metabolism
  • 11:50h: Invited Talk (15min+5min) – Paulo Oliveira*, Coimbra. A mitochondrial approach to cardiovascular disease
  • 12:20h: Invited Talk (15min+5min) – Gabriele Schiattarella, Berlin*. Lipid-based alterations in heart failure with preserved ejection fraction (HFpEF)
  • 12:40h: Invited Talk (15min+5min) – Eldad Tzahor*, Rehovot. ERBB2-YAP and AGRIN regenerative signals in the mammalian heart

  • 13:00h  | Sojourn

Georg Hansmann on behalf of the European Pediatric Pulmonary Vascular Disease Network

Right Heart Failure

Transthoracic echocardiography (parasternal short axis view) shows RV hypertrophy, severe RV dilation and systolic RV dysfunction.

„Advanced Therapies for Pediatric Pulmonary Hypertension and Heart Failure“

Workshop | Friday, June 10, 2022 (9:00-17:00h) | Charité and DHZB, Germany

Hosted by
The European Pediatric Pulmonary
Vascular Disease Network

Venue:
Charité Campus Virchow-Klinikum and DHZB, Berlin, Germany

5-10 Course Instructors
Max. 40 Participants
Flat rate 50,- EUR (in addition to symposium fee)

To register for this workshop please contact: workshop@pvdnetwork.org

Don’t miss our PH/HF Workshop!

Pediatric PH is caused by multiple underlying conditions, with and without congenital heart disease. The current management of pediatric patients with PH incorporates several different diagnostic and therapeutic modalities, which are used in a variety of settings ranging from ambulatory to intensive care. The aim of this workshop is to provide a contemporary overview of current diagnostic strategies and treatment approaches used in different forms of pediatric PH by means of hands-on teaching and small-group discussions. During the morning sessions (09.00-13.00) we will cover the following topics:

  • Echocardiographic assessment of PH and right heart function

  • Invasive assessment of pediatric PH and vasoreactivity testing

  • Principles of intensive care in pediatric PH with and without CHD

  • Extracorporal circulatory support in PH and RV failure

In the afternoon (14.00-17-00) we will discuss typical and rather rare case scenarios in pediatric PH. Participants are encouraged to bring their own cases and discuss them with faculty and the other participants. The workshop is intended for all medical personnel taking care of pediatric PH patients, such as pediatric residents, fellows, early-career pediatric cardiologists, pulmonologists and neonatologists. It will take place at the Department of Pediatric Cardiology, Charité Berlin and the Department of Congenital Heart Disease, German Heart Center Berlin (DHZB), both located at Virchow Campus of Charité University Hospital. We are looking forward to welcoming you in the heart of Berlin!

Symposium Venue

The GLS Campus is located in the heart of Berlin’s Prenzlauer Berg district. Surrounded by well known cafes, bars and restaurants, our symposium venue offers a unique combination of urban lifestyle and scientific retreat. Public transport is in walking distance.

Hotel recommendations

There is a variety of hotels next to our symposium venue. We recommend two hotels in particular: The famous „Oderberger Hotel“ is located in walking distance from our symposium venue. The hotel used to be an impressive public bath a century ago. Now it accommodates tourists on a 4 star level. Another interesting hotel near our symposium venue is „Die Schule“.

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for the 2nd International Pulmonary Hypertension / Heart Failure Symposium
NEW DATE: June 11 – 12, 2022

Start registration by clicking this box!

(Accessible by July 1, 2021)

Our professional conference organizer (PCO) will confirm your registration by Email, by the end of the month when the full registration fee is wire transfered to the EPPVDN’s bank account (please use IBAN). You are registered when the registration fee has been wire transfered.

Please note that the fees depend on your work status (trainee or staff) and on the date the registration fee is transfered. Please upload the confirmation of trainee status, if applicable.

Cancellation terms:

All cancellations must be made timely and in writing to the PCO.

  1. Free cancellations and full reembursements of the registration fees will be possible by April 17, 2022 (Easter Sunday).
  2. For cancellations made in writing between April 18 and April 30, 2022, only 50% of the registration fees will be reembursed, and 50% will be deducted as administration fee.
  3. After April 30, 2022, no cancellations and reembursement of registration fees will be possible.

In case this event will need to be postponed or cancelled (e.g., because of the pandemic COVID-19), you will get informed ASAP.

Registration:

Reduced registration fees for students/trainees (residents, clinical fellows, PostDocs; not faculty)

Early Bird registration:

  • 180 Euro reduced Early Bird (student/trainee*):
    Any registration by April 17, 2022

  • 290 Euro regular Early Bird (non-trainee):
    Any registration by April 17, 2022

  • Free cancellation possible by April 17, 2022

Standard registration fees (in-time):

  • 240 Euro – reduced (student/trainee*):
    registration April 18, 2022 – May 22, 2022

  • 350 Euro – regular (non-trainee):
    registration April 18, 2022 – May 22, 2022

On site (after May 22, 2022), cash only:

  • 290 Euro – reduced for students/trainees* (*defined as students, residents, fellows, PostDocs)

  • 400 Euro – regular (non-trainee)

Single day tickets are not available.

Abstract Submission

Scientific Abstracts can be submitted between January 1 and May 8, 2022 here via mail@pvdnetwork.org. We are looking forward to learning about your research. From all submissions, we will select ca. 20 abstracts for poster or oral presentation, and notify you about the decision by May, 2022.