Projekt Beschreibung

Pulmonary Hypertension Symposium – Update 2016

April 8, 2016 (8:00-17:00h)
Hannover Medical School, Germany

Hosted by The European Pediatric Pulmonary Vascular Disease Network

Venue: Zahnklinik (Building K20), Hörsaal P (Lecture Hall P), Carl-Neuberg-Str. 1, 30625 Hannover, GER

Agenda: 4 sessions (2 interdisciplinary in AM; 1 pediatric and 1 adult in PM), plus keynote lectures. 15min. talks, plus 5 minutes discussion, 1 panel discussion, posters, consensus statements, industry exhibition.

Scientific lead: Prof. Dr. Georg Hansmann

Endorsed by:

Welcome to Hannover!

We cordially invite you to participate in the international, interdisciplinary “Pulmonary Hypertension Symposium – Update 2016”. A strength of this meeting is its multidisciplinary nature – bringing together basic-translational scientists and clinicans (cardiologists, pulmonologists, neonatologists, thoracic surgeons, intensivists). The first session concentrates on basic mechanisms and genetics, the other 3 sessions have strong clinical focus. This meeting will update you on recent discoveries and innovations, and addresses several important paradigm shifts in the field of pulmonary hypertension and heart failure:

  • Pulmonary vascular disease relates in large part to increased cell proliferation, metabolic dysfunction, resistance to apoptosis, and inflammation (rather than vasoconstriction) – „cancer hypothesis“.

  • The impact of epigenetic regulation and gene mutations on pulmonary arterial hypertension (PAH) phenotypes is increasingly recognized. In addition, stem cells, progenitor and differentiated blood cells play important roles in PAH development.

  • The right ventricle, and its interaction with the left ventricle, is the key determinant of prognosis in PAH. Thus, innovative, non-invasive imaging of the hypertensive RV-PA unit, and the search for direct RV treatment targets, are paramount.

  • The heterogenous pre- and postnatal etiologies and unique features of pediatric pulmonary hypertensive vascular disease justify specific expert consensus statements and recommendations that will be highlighted throughout this meeting.

Histology of advanced PVD

Pulmonary vascular disease (PVD) is characterized by progressive obliteration of pulmonary arterioles leading to increased pulmonary vascular resistance (PVR), pulmonary arterial hypertension (PAH), right heart failure, and death in ≈25-60% of patients 5 years after diagnosis. The pathobiology of PAH is complex and multifactorial, and none of the current therapies has been shown to be universally effective or able to reverse advanced pulmonary vascular disease, characterized by plexiform vascular lesions (image).

08:00 – 12:00h  |  Morning Program

*confirmed speakers, chairs and panelists

  • 08:00 – 08:30h  |  Registration

  • 08:30 – 10:00h  |  Session 1

„Update on Pathobiology, Biomarkers and Genetics in PAH“

  1. Georg Hansmann*, Hannover: Welcome
  2. Juha Koskenvuo*, Helsinki: “Genetics of PAH”
  3. Danny Jonigk*, Hannover: “Dissecting the pulmonary vasculature in PAH”
  4. Keynote Lecture #1: Daniel Greif*, Yale University: „Specialized smooth muscle progenitors and arteriole remodeling in pulmonary hypertension“
  • Chairs: Anne Hilgendorff*, Munich; Philippe Boucher*, Strassbourgh; Christian Apitz*, Ulm.
  • 10:00 – 10:30h  |  Coffee break

Network posters, industry exhibition

  • 10:30 – 12:00h  |  Session 2

„Imaging the hypertensive RV-PA unit“

  1. Jens Vogel-Claussen*, Hannover: “MRI/CT in PAH diagnostics – just do it ?”
  2. Shahin Moledina*, London: “MRI hemodynamics and prognosis in PAH”
  3. Rolf Berger*, Groningen: “Clinical worsening and echo treatment targets in PAH”
  4. Heiner Latus*, Gießen: “Cardiac MRI in PH and RV Dysfunction”
  • Chairs: Philipp Beerbaum*, Hannover; Martin Koestenberger*, Graz; Astrid Lammers*, Münster.

12:00 – 13:00h  |  Lunch Break

Network posters, PH consensus statements/guidelines, industry exhibition

Rationale for an Expert Consensus Statement on Pediatric Pulmonary Hypertension

  • Diagnostic and therapeutic strategies in children with PH are markedly influenced by unique features of the pulmonary circulation in childhood (developmental biology), and certain pediatric diseases which are commonly associated with PH.
  • A new WSPH classification was published in December 2013, and slightly modified in the new 2015 ESC/ERS guidelines – a document that mainly focuses on the clinical care in adults.
  • Yet, comprehensive, detailed but practical recommendations addressing the specifics of pulmonary hypertension and pulmonary vascular disease in children have been lacking.

13:00 – 17:00h  |  Afternoon Program

*confirmed speakers, chairs and panelists

  • 13:00 – 14:15h  |  Session 3

„Interventions for Advanced PAH in the Young“

  1. Martin Wetzke*/Gregor Warnecke*, Hannover: “Lung transplantation for endstage pediatric PAH”
  2. Damien Bonnet*, Paris: “Potts shunt for endstage PAH”
  3. Peter Ewert*, Munich: “When to close a shunt in PAH-CHD (VSD, PDA) interventionally…”
  4. Pro and Con discussion: “Default lung transplantation in endstage PAH?”
  • Chairs: Damien Bonnet*, Paris; Dietmar Schranz*, Gießen; Felix Berger*, Berlin.
  • Panelists: Harald Bertram*, Ingo Dähnert*, Peter Ewert*, Matthias Gorenflo, Georg Hansmann*, Astrid Lammers*, Brigitte Stiller, Gregor Warnecke*, Babar Hasan*.
  • 14:15 – 15:00h  |  Coffee break

Network posters, PH consensus statements/guidelines, industry exhibition

  • 15:00 – 16:45h  |  Session 4

„PAH and Heart Failure“

  1. Soni Pullamsetti*, Bad Nauheim: “FoxO1 in the hypertensive lung”
  2. Marie-José Goumans*, Leiden: „TGF-β signaling in heart failure”
  3. Stephan Rosenkranz*, Cologne: “Pharmacotherapy of RV failure”
  4. Johann Bauersachs*, Hannover: “Mineralocorticoidreceptor antagonists in heart failure”
  • Chairs: Gerhard Diller*, Münster; Harald Bertram*, Hannover; Jörg Heineke*, Hannover.
  • 16:45 – 17:00h  |  Adjourn

Georg Hansmann – on behalf of the European Pediatric Pulmonary Vascular Disease Network

“Providing Clinical Care for Children with PH”

Workshop on Thursday, April 7, 2016 (8:30-17:00h) Hannover Medical School, Germany

Hosted by
The European Pediatric Pulmonary
Vascular Disease Network

Pädiatrisches Forschungszentrum (PFZ)
Building J10, ground level, room S0
Carl-Neuberg-Str. 1
30625 Hannover

Scientific lead: Prof. Dr. Georg Hansmann

Don’t miss our PH Workshop!

This is one of the very first full day PH workshops with hands-on sessions in small groups (4 rotations). The workshop is geared to clinicans on senior resident, fellow or attending level. The content of the practical sessions in the morning (echocardiography, catheterization laboratory, intensive care unit, ECMO) can be applied to pediatric and adult medicine. However, the cases in the afternoon will have a focus on pediatric PH, and PH associated with congenital heart disease. Special features of this PH workshop:

  • Hands on course (rotations: echo lab, cath lab, ICU, ECMO)
  • Oral Presentation (echo)
  • Clinical cases / Meet the experts
  • Bring your cases (please prepare 10-15min presentation)

The workshop will start with registration in the pediatric research center at Hannover Medical School, followed by an overview talk on echocardiographic assessment of PH and heart failure. Participants will then be divided in approx. 5-6 colleagues per group. Teaching language is English or German, depending on the composition of the group (max. 40 participants).

Thanks for supporting our PH Workshop & Symposium:

4000,- Euro

4000,- Euro

3000,- Euro

2000,- Euro

1000,- Euro